Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Pixantrone dimaleate (Pixantrone Maleate) 是一种拓扑异构酶 II 的抑制剂和 DNA 嵌入剂,是一种实验性抗肿瘤药物。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 195 | 现货 | ||
5 mg | ¥ 493 | 现货 | ||
10 mg | ¥ 747 | 现货 | ||
25 mg | ¥ 1,280 | 现货 | ||
50 mg | ¥ 1,930 | 现货 | ||
100 mg | ¥ 2,890 | 现货 | ||
500 mg | ¥ 6,590 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 597 | 现货 |
产品描述 | Pixantrone dimaleate (Pixantrone Maleate) (BBR 2778 dimaleate) is an experimental antineoplastic drug. |
激酶实验 | Recombinant RT enzymes are expressed, purified, and assessed for inhibition by Efavirenz (L-743726). Ki and Kii values are determined for each enzyme tested. The wild-type RT exhibited exclusively noncompetitive inhibition kinetics (data not shown), and, therefore, the Ki and Kii values are identical. Pure noncompetitive inhibition is not assumed for the mutant enzymes, and, hence, the values of both Ki and Kii are obtained from the linear mixed-type inhibition equation. The two- to threefold differences between the Ki and Kii values probably reflect a small contribution of competitive inhibition with the mutant RTs[1]. |
别名 | 匹克生琼来酸盐, BBR-2778, Pixantrone Maleate, BBR 2778 dimaleate, 马来酸匹衫琼 |
分子量 | 557.21 |
分子式 | C25H27N5O10 |
CAS No. | 144675-97-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 91 mg/mL(163.3 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.7947 mL | 8.9733 mL | 17.9466 mL | 44.8664 mL |
5 mM | 0.3589 mL | 1.7947 mL | 3.5893 mL | 8.9733 mL | |
10 mM | 0.1795 mL | 0.8973 mL | 1.7947 mL | 4.4866 mL | |
20 mM | 0.0897 mL | 0.4487 mL | 0.8973 mL | 2.2433 mL | |
50 mM | 0.0359 mL | 0.1795 mL | 0.3589 mL | 0.8973 mL | |
100 mM | 0.0179 mL | 0.0897 mL | 0.1795 mL | 0.4487 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Pixantrone dimaleate 144675-97-8 DNA Damage/DNA Repair Topoisomerase K562 cell BBR 2778 inhibit Inhibitor intercalator MDCK cell Pixantrone Dimaleate Pixantrone 匹克生琼来酸盐 BBR-2778 Pixantrone Maleate BBR2778 Dimaleate BBR-2778 Dimaleate anti-tumor BBR 2778 dimaleate BBR 2778 Dimaleate 马来酸匹衫琼 BBR2778 DNA inhibitor